The paper explores the peculiarities of the bilateral Egyptian-American relations in recent period, when a change of the highest political leadership in both states took place. Egypt as one of the most influential countries of the Middle East and North Africa occupies an important place in the Middle East policy of the United States. The new US administration has been developing a new strategy in the Middle East, including the ARE, trying to find new approaches to conducting its foreign policy course in the region. In the context of high-level diplomacy carried out by Washington and Cairo, the authors assess the level of these relationships as well as the steps taken by Egypt in the international arena, aimed at ensuring its own national interests, maintaining stability and security in the region. The factors influencing the level of bilateral cooperation, based on long-standing ties in the trade-economic and military-technical fields are also analyzed. The paper highlights the reasons for the observed «cooling» in Egyptian-American relations. As the Egyptian press notes, Washington is putting pressure on the Egyptian leadership, using issues related to democratization and human rights. The problem of Cairo’s choice of strategic partners is also considered. This process occurs in the context of the increasing complexity of the regional situation as well as the global one, characterized by dynamism and sometimes unpredictability. Particular attention is paid to the assessment of bilateral Egyptian-American relations at the present stage contained in the Egyptian mass media.